Pfizer Inc. (PFE) vs Spyre Therapeutics, Inc. (SYRE)
The same free fields, in the same order, for both companies, so a figure on one line can be read straight across.
This page states measurements and nothing else. It does not rank the two companies, name one of them, or draw a conclusion from the figures.
Data as of Oct 27, 2026, for both companies.
The figures, field by field
A dash means the snapshot carries no figure for that company on that line. A line is dropped only when neither company has it, so a dash beside a figure is a fact about coverage, not about either company.
| PFE | SYRE | |
|---|---|---|
| Sector | Healthcare | Healthcare |
| Industry | Drug Manufacturers - General | Biotechnology |
| Size band | LARGE | MID |
| Listing | NYSE | Nasdaq GS |
| Country | United States | United States |
| Theme | pharmaceuticals-large-cap | — |
| Price and returns | ||
| Last close | $29.79 | $92.91 |
| Return · 1 week | +1.19% | +9.67% |
| Return · 1 month | +3.73% | +8.30% |
| Return · 3 months | +17.98% | −7.05% |
| Return · year to date | +22.28% | +203.83% |
| Return · 1 year | +26.49% | +278.14% |
| Distance from the 52-week highThe last close measured against the highest close of the past 52 weeks. | −2.14% | −15.67% |
| 52-week high | $30.44 | $110.18 |
| 52-week low | $23.62 | $21.15 |
| Size and turnover | ||
| Market value · USDConverted to US dollars, so two companies listed in different currencies sit under one heading. | $169.79B | $8.44B |
| Turnover · median day, USDThe median value traded in a session over the past 50 sessions. | $929.52M | $105.19M |
| Employees | 75,000 | 125 |
| Valuation | ||
| Price to earnings · trailing | 39.00× | n/a (negative earnings) |
| Price to earnings · forward | 10.41× | n/a (negative forward earnings) |
| Price to sales | 2.69× | — |
| Price to book | 2.01× | 7.90× |
| Enterprise value to EBITDA | 8.80× | — |
| Enterprise value to revenue | 3.51× | — |
| PEG ratio | 13.76 | — |
| Earnings per share · trailing | 0.77 | -1.92 |
| Profitability | ||
| Gross margin | 73.18% | — |
| Operating margin | 27.88% | 0.00% |
| Profit margin | 6.81% | — |
| Return on equity | 5.01% | −22.98% |
| Return on assets | 5.78% | −19.81% |
| Growth | ||
| Revenue growth | +2.60% | — |
| Balance sheet and payout | ||
| Debt / equity (%) | 74.25 | — |
| Current ratio | 1.27 | 18.53 |
| Dividend yield | 5.73% | 0.00% |
| Payout ratio | 226.32% | — |
| Trend and volatility | ||
| RSI · 14 | 61.82 | 54.14 |
| ADX · 14 | 28.95 | 17.15 |
| 50-day average | $28.36 | $90.97 |
| 200-day average | $26.71 | $71.58 |
| Average true range · share of priceAverage true range over 14 sessions, stated as a share of the last close, so it can be read across two share prices. | 1.96% | 5.62% |
The full PFE analysis
Everything this table leaves out for Pfizer Inc.: the plain-language summary and key points, the accumulation read, signal history, full fundamentals, market context, and the case each side of the PFE argument makes.
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Open the full PFE analysisThe full SYRE analysis
Everything this table leaves out for Spyre Therapeutics, Inc.: the plain-language summary and key points, the accumulation read, signal history, full fundamentals, market context, and the case each side of the SYRE argument makes.
$9.90 per stock, one time, 30 days of access.
Open the full SYRE analysis