Largest one day declines
The 50 largest one day percentage moves lower recorded at the latest close. The largest moves were GENB at −20.8% and SYRE at −12.8%. By size, the list splits into 12 large cap and 38 mid cap listings.
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| Ticker | Company | Market cap (USD) | Size | 1D return | 1Y return |
|---|---|---|---|---|---|
| GENB | Generate Biomedicines, Inc. | $2.07B | Mid cap | −20.80% | +27.59% |
| SYRE | Spyre Therapeutics, Inc. | $8.13B | Mid cap | −12.81% | +446.12% |
| SIG.AX | Sigma Healthcare Limited | $21.65B | Large cap | −8.80% | −15.21% |
| M1RN34.SA | Moderna, Inc. | $63.51B | Large cap | −6.11% | +462.13% |
| HIMS | Hims & Hers Health, Inc. | $6.96B | Mid cap | −6.05% | −32.22% |
| MRNA | Moderna, Inc. | $59.75B | Large cap | −5.77% | +496.25% |
| RLAY | Relay Therapeutics, Inc. | $4.26B | Mid cap | −5.40% | +445.10% |
| 128940.KS | Hanmi Pharm. Co., Ltd. | $4.63B | Mid cap | −5.09% | +66.34% |
| TLX | Telix Pharmaceuticals Limited | $3.77B | Mid cap | −4.79% | −8.02% |
| BFLY | Butterfly Network, Inc. | $2.30B | Mid cap | −4.42% | +450.32% |
| IOVA | Iovance Biotherapeutics, Inc. | $3.66B | Mid cap | −4.27% | +233.88% |
| CAI | Caris Life Sciences, Inc. | $7.58B | Mid cap | −4.25% | −29.83% |
| JAZZ | Jazz Pharmaceuticals plc | $16.89B | Large cap | −4.20% | +100.35% |
| 000100.KS | Yuhan Corporation | $4.50B | Mid cap | −4.15% | −27.54% |
| BLLN | BillionToOne, Inc. | $4.54B | Mid cap | −3.85% | −11.68% |
| GRAL | GRAIL, Inc. | $3.55B | Mid cap | −3.57% | +136.66% |
| 326030.KS | SK Biopharmaceuticals Co., Ltd. | $4.89B | Mid cap | −3.49% | −11.24% |
| BSX | Boston Scientific Corporation | $69.81B | Large cap | −3.39% | −54.50% |
| B1AX34.SA | Baxter International Inc. | $13.60B | Large cap | −3.38% | +3.61% |
| BHC | Bausch Health Companies Inc. | $2.43B | Mid cap | −3.27% | −10.45% |
| ACAD | ACADIA Pharmaceuticals Inc. | $5.07B | Mid cap | −3.24% | +11.33% |
| IRTC | iRhythm Holdings, Inc. | $4.06B | Mid cap | −3.20% | −29.83% |
| BLTE | Belite Bio, Inc | $6.31B | Mid cap | −3.09% | +144.07% |
| B1SX34.SA | Boston Scientific Corporation | $70.04B | Large cap | −3.08% | −89.24% |
| CORT | Corcept Therapeutics Incorporated | $12.95B | Large cap | −3.05% | +71.81% |
| CURA.TO | Curaleaf Holdings, Inc. | $2.51B | Mid cap | −3.02% | +197.74% |
| BHC.TO | Bausch Health Companies Inc. | $2.43B | Mid cap | −3.01% | −9.88% |
| XNCR | Xencor, Inc. Common Stock | $2.11B | Mid cap | −2.94% | +254.61% |
| LEGN | Legend Biotech Corporation | $4.02B | Mid cap | −2.91% | −40.44% |
| EBO.AX | EBOS Group Limited | $2.60B | Mid cap | −2.89% | −37.83% |
| CRSP | CRISPR Therapeutics AG | $5.73B | Mid cap | −2.74% | +10.65% |
| BEAM | Beam Therapeutics Inc. | $3.21B | Mid cap | −2.71% | +79.06% |
| MBX | MBX Biosciences, Inc. | $3.22B | Mid cap | −2.71% | +366.53% |
| RCUS | Arcus Biosciences, Inc. | $3.92B | Mid cap | −2.57% | +191.29% |
| SLS | SELLAS Life Sciences Group, Inc. | $2.77B | Mid cap | −2.56% | +615.10% |
| ALK-B.CO | ALK-Abelló A/S | $7.26B | Mid cap | −2.52% | +5.09% |
| GRFS | Grifols, S.A. | $5.38B | Mid cap | −2.35% | −19.39% |
| ORKA | Oruka Therapeutics, Inc. | $6.58B | Mid cap | −2.34% | +555.07% |
| DFTX | Definium Therapeutics, Inc. | $5.88B | Mid cap | −2.32% | +344.37% |
| 008930.KS | Hanmi Science Co., Ltd. | $2.11B | Mid cap | −2.25% | +2.80% |
| REGN | Regeneron Pharmaceuticals, Inc. | $83.89B | Large cap | −2.25% | +39.36% |
| IMNM | Immunome, Inc. | $3.34B | Mid cap | −2.16% | +188.94% |
| ZBIO | Zenas BioPharma, Inc. | $2.15B | Mid cap | −2.16% | +97.73% |
| RDOR3.SA | Rede D'Or São Luiz S.A. | $14.92B | Large cap | −2.13% | +1.37% |
| IDYA | IDEAYA Biosciences, Inc. | $4.01B | Mid cap | −2.12% | +66.32% |
| 000105.KS | Yuhan Corporation | $3.84B | Mid cap | −2.08% | −32.04% |
| ABCL | AbCellera Biologics Inc. | $3.97B | Mid cap | −2.08% | +181.38% |
| HALO | Halozyme Therapeutics, Inc. | $12.41B | Large cap | −2.07% | +46.30% |
| MESO | Mesoblast Limited | $2.23B | Mid cap | −2.04% | +4.47% |
| DC4.DE | DexCom, Inc. | $33.35B | Large cap | −2.02% | +21.06% |
Covers ~22,000 companies across the US, Europe and Asia-Pacific (ex mainland China, Hong Kong and India), refreshed nightly. Every listed stock opens as a full analysis for $9.90.
Micro and small cap listings are left out, so the list describes the market rather than thin trading, as are moves beyond 1,000% in a session, which are corporate actions the price series has not been restated for. This is a description of one day of price movement, nothing more. It says nothing about any company behind it.