Theme hub · 227 companies

Rare disease stocks

Daily analysis · Oct 27, 2026

Today's data shows 82 companies rose, 80 fell and one was unchanged, while median one-year changes by size band ranged from +31.5% for mid caps to -51.5% for micro caps.

Generated from today's data · Not investment advice

Heavily traded in Rare disease

Turnover over $10M/day

75 of about 230 companies in this theme turn over more than $10M in a typical session. Largest market value first. Data as of Oct 27, 2026.

CompanyTurnover1Y returnNext report
VRTXVertex Pharmaceuticals Incorporated$494.46M+23.16%Reports Nov 2, 2026
ARGXargenx SE$241.59M+4.76%—
ALNYAlnylam Pharmaceuticals, Inc.$325.24M−52.43%Reports Oct 29, 2026
ROIVRoivant Sciences Ltd.$222.91M+91.65%Reports Nov 9, 2026
INSMInsmed Incorporated$194.09M−43.10%Reports Oct 29, 2026
ASNDAscendis Pharma A/S$159.80M+20.63%—
JAZZJazz Pharmaceuticals plc$149.80M+47.64%Reports Nov 2, 2026
BBIOBridgeBio Pharma, Inc.$169.79M+7.22%Reports Oct 29, 2026

Turnover is the median value traded in one session, measured over the past 50 sessions. It describes trading activity in a stock and nothing about the company behind it.

Table

227 companies, largest market value first.

Data as of Oct 27, 2026 · updates nightly, Mon–Sat

TickerCompanyMarket cap (USD)Size1Y return
VRTXVertex Pharmaceuticals Incorporated$131.08BLarge cap+23.16%
ARGXargenx SE$54.67BLarge cap+4.76%
ALNYAlnylam Pharmaceuticals, Inc.$30.46BLarge cap−52.43%
A1LN34.SAAlnylam Pharmaceuticals, Inc.$30.20BLarge cap−52.23%
ROIVRoivant Sciences Ltd.$26.04BLarge cap+91.65%
INSMInsmed Incorporated$20.38BLarge cap−43.10%
ASNDAscendis Pharma A/S$16.13BLarge cap+20.63%
JAZZJazz Pharmaceuticals plc$13.35BLarge cap+47.64%
BBIOBridgeBio Pharma, Inc.$13.32BLarge cap+7.22%
BMRNBioMarin Pharmaceutical Inc.$10.79BLarge cap+5.85%
CORTCorcept Therapeutics Incorporated$9.42BMid cap+20.07%
KYMRKymera Therapeutics, Inc.$9.21BMid cap+88.73%
PTGXProtagonist Therapeutics, Inc.$9.08BMid cap+86.47%
CRNXCrinetics Pharmaceuticals Inc$9.01BMid cap+91.59%
CYTKCytokinetics, Incorporated$8.51BMid cap+0.91%
ARWRArrowhead Pharmaceuticals, Inc.$8.31BMid cap+49.39%
4151.TKyowa Kirin Co., Ltd.$8.14BMid cap+4.15%
IONSIonis Pharmaceuticals, Inc.$7.22BMid cap−40.51%
RYTMRhythm Pharmaceuticals, Inc.$6.14BMid cap−19.79%
IMVTImmunovant, Inc.$5.82BMid cap+31.45%
MANEVeradermics, Incorporated$5.74BMid cap+263.95%
KNSAKiniksa Pharmaceuticals International, plc$5.61BMid cap+79.75%
MIRMMirum Pharmaceuticals, Inc.$5.41BMid cap+16.33%
GRFSGrifols, S.A.$5.39BMid cap−15.57%
ORKAOruka Therapeutics, Inc.$5.31BMid cap+226.10%
PTCTPTC Therapeutics, Inc.$5.10BMid cap−8.96%
SRRKScholar Rock Holding Corporation$5.08BMid cap+36.75%
TVTXTravere Therapeutics, Inc.$4.65BMid cap+67.85%
DNTHDianthus Therapeutics, Inc.$4.34BMid cap+136.66%
EWTXEdgewise Therapeutics, Inc.$4.25BMid cap+144.35%
ARQTArcutis Biotherapeutics, Inc.$4.00BMid cap+61.97%
LQDALiquidia Corporation$3.92BMid cap+92.18%
IRONDisc Medicine, Inc.$3.45BMid cap−13.37%
AMLXAmylyx Pharmaceuticals, Inc.$3.40BMid cap+90.37%
DYNDyne Therapeutics, Inc.$2.94BMid cap−34.96%
VRDNViridian Therapeutics, Inc.$2.64BMid cap+3.55%
ADMAADMA Biologics, Inc.$2.48BMid cap−29.07%
CLDXCelldex Therapeutics, Inc.$2.32BMid cap+7.78%
AUPHAurinia Pharmaceuticals Inc.$2.27BMid cap+38.65%
PHVSPharvaris N.V.$2.21BMid cap+38.21%
AGIOAgios Pharmaceuticals, Inc.$2.20BMid cap−14.46%
VERAVera Therapeutics, Inc.$2.02BMid cap−6.94%
BCRXBioCryst Pharmaceuticals, Inc.$2.01BMid cap+7.80%
SEPNSepterna, Inc.$1.89BSmall cap+82.94%
XERSXeris Biopharma Holdings, Inc.$1.86BSmall cap+9.67%
MLYSMineralys Therapeutics, Inc.$1.81BSmall cap−49.31%
PVLAPalvella Therapeutics, Inc.$1.80BSmall cap+79.23%
TRVITrevi Therapeutics, Inc.$1.78BSmall cap+19.14%
ZBIOZenas BioPharma, Inc.$1.78BSmall cap−14.34%
NEU.AXNeuren Pharmaceuticals Limited$1.75BSmall cap−12.52%
MAZEMaze Therapeutics, Inc.$1.73BSmall cap+0.23%
COAGHemab Therapeutics Holdings, Inc.$1.68BSmall cap+5.94%
ANIPANI Pharmaceuticals, Inc.$1.67BSmall cap−21.82%
STOKStoke Therapeutics, Inc.$1.64BSmall cap−22.85%
FBRXForte Biosciences Inc$1.63BSmall cap+492.23%
RAREUltragenyx Pharmaceutical Inc.$1.59BSmall cap−54.46%
TRAXFirst Tracks Biotherapeutics, Inc.$1.55BSmall cap+128.84%
009420.KSHanall Biopharma Co., Ltd.$1.48BSmall cap+15.52%
4516.TNippon Shinyaku Co., Ltd.$1.46BSmall cap+4.08%
ANABAnaptysBio, Inc.$1.46BSmall cap+102.20%
KALVKalVista Pharmaceuticals Inc$1.44BSmall cap+140.43%
ETONEton Pharmaceuticals, Inc.$1.43BSmall cap+171.48%
TYRATyra Biosciences, Inc.$1.40BSmall cap+37.60%
NKTRNektar Therapeutics$1.28BSmall cap−40.15%
SLNSilence Therapeutics plc$1.23BSmall cap+177.03%
PYC.AXPYC Therapeutics Limited$1.21BSmall cap+43.85%
AVLNAvalyn Pharma Inc.$1.20BSmall cap−7.97%
OMEROmeros Corporation$1.18BSmall cap+111.28%
006280.KSGC Biopharma Corp.$1.14BSmall cap+0.62%
MLTXMoonLake Immunotherapeutics$1.01BSmall cap+17.28%
JBIOJade Biosciences, Inc.$922.16MSmall cap+42.30%
SVRASavara Inc.$864.79MSmall cap+3.20%
PHARPharming Group N.V.$842.26MSmall cap−10.73%
ANNXAnnexon, Inc.$701.44MSmall cap+4.52%
DSGNDesign Therapeutics, Inc.$647.09MSmall cap+48.35%
GYREGyre Therapeutics, Inc.$643.62MSmall cap−24.31%
WVEWave Life Sciences, Inc.$632.52MSmall cap−57.87%
CRMDCorMedix Inc.$618.88MSmall cap−28.14%
DBVTDBV Technologies S.A.$612.77MSmall cap−37.59%
ZVRAZevra Therapeutics, Inc.$582.55MSmall cap−13.99%
IRWDIronwood Pharmaceuticals, Inc.$578.34MSmall cap+114.72%
005257.KSGC Corp.$565.94MSmall cap−33.38%
STTKShattuck Labs, Inc.$550.99MSmall cap+168.93%
VALNValneva SE$512.99MSmall cap−41.58%
CLYMClimb Bio, Inc.$506.01MSmall cap+319.52%
AQSTAquestive Therapeutics, Inc.$502.05MSmall cap−43.29%
KMDAKamada Ltd.$458.22MSmall cap+16.37%
AGMBAgomAb Therapeutics NV$422.06MSmall cap−41.50%
ASMBAssembly Biosciences, Inc.$400.49MSmall cap−33.99%
4552.TJCR Pharmaceuticals Co., Ltd.$400.36MSmall cap−13.24%
TECXTectonic Therapeutic, Inc.$390.01MSmall cap+7.14%
SPRYARS Pharmaceuticals, Inc.$389.83MSmall cap−59.00%
RZLTRezolute, Inc.$369.48MSmall cap−59.58%
AVTXAvalo Therapeutics, Inc.$363.08MSmall cap−62.37%
ZURAZura Bio Limited$341.15MSmall cap−9.41%
ENTAEnanta Pharmaceuticals, Inc.$339.02MSmall cap+14.29%
AVIRAtea Pharmaceuticals, Inc.$333.65MSmall cap+28.00%
XFORX4 Pharmaceuticals, Inc.$322.23MSmall cap−13.10%
TTRXTurn Therapeutics Inc.$322.20MSmall cap+113.48%
FULCFulcrum Therapeutics, Inc.$278.03MSmall cap−62.28%
QTTBQ32 Bio Inc.$251.55MSmall cap+201.79%
CUV.AXClinuvel Pharmaceuticals Limited$248.43MSmall cap−38.51%
LRMRLarimar Therapeutics, Inc.$244.12MSmall cap−48.39%
IFRXInflaRx N.V.$232.10MSmall cap−5.12%
SLGLSol-Gel Technologies Ltd.$227.38MSmall cap+74.91%
KROSKeros Therapeutics, Inc.$224.64MSmall cap−24.62%
SIGASIGA Technologies, Inc.$224.17MSmall cap−57.69%
IKTInhibikase Therapeutics, Inc.$212.09MSmall cap−2.56%
CAMPCAMP4 THERAPEUTICS CORPORATION$201.44MSmall cap−17.69%
PLXProtalix BioTherapeutics, Inc.$199.82MSmall cap+4.20%
0AB6.LHyloris Pharmaceuticals SA$185.32MSmall cap−28.56%
TRDAEntrada Therapeutics, Inc.$184.95MSmall cap−35.02%
PRQRProQR Therapeutics N.V.$182.04MSmall cap−56.64%
IVVDInvivyd, Inc.$180.81MSmall cap−72.60%
ELDNEledon Pharmaceuticals, Inc.$179.59MSmall cap−42.30%
AKBAAkebia Therapeutics, Inc.$178.40MSmall cap−79.69%
PEPGPepGen Inc.$172.46MSmall cap−54.14%
SIONSionna Therapeutics, Inc.$166.83MSmall cap−90.37%
MDWDMediWound Ltd.$155.76MSmall cap−34.41%
UPBUpstream Bio, Inc.$150.62MSmall cap−88.34%
RNAAtrium Therapeutics, Inc.$140.27MSmall cap−45.42%
ANTXAN2 Therapeutics, Inc.$133.96MSmall cap+168.89%
SPRBSpruce Biosciences, Inc.$129.76MSmall cap−64.24%
ARMPArmata Pharmaceuticals, Inc.$128.28MSmall cap−34.54%
PAR.AXParadigm Biopharmaceuticals Limited$107.73MSmall cap−44.94%
PYPDPolyPid Ltd.$106.64MSmall cap+46.54%
UNCYUnicycive Therapeutics, Inc.$98.07MMicro cap−31.68%
INOInovio Pharmaceuticals, Inc.$92.76MMicro cap−65.07%
RLYBRallybio Corporation$88.40MMicro cap+233.00%
PLYXPolaryx Therapeutics, Inc.$86.16MMicro cap−94.80%
DXB.AXDimerix Limited$84.29MMicro cap−60.78%
MISTMilestone Pharmaceuticals Inc.$80.23MMicro cap−66.26%
EQEquillium, Inc.$79.26MMicro cap−8.76%
TELOTelomir Pharmaceuticals, Inc.$73.51MMicro cap−36.40%
FBIOPFortress Biotech, Inc.$71.45MMicro cap+130.77%
RCE.AXRecce Pharmaceuticals Ltd$69.76MMicro cap−21.69%
RFLRafael Holdings, Inc.$68.12MMicro cap−12.59%
CPIXCumberland Pharmaceuticals Inc.$65.18MMicro cap+36.36%
ILA.AXIsland Pharmaceuticals Limited$64.39MMicro cap−21.52%
TENXTenax Therapeutics, Inc.$64.37MMicro cap−78.13%
FBIOFortress Biotech, Inc.$62.37MMicro cap−27.24%
SPROSpero Therapeutics, Inc.$62.31MMicro cap−53.28%
PTHSPelthos Therapeutics Inc.$58.19MMicro cap−52.50%
4599.TStemRIM$56.89MMicro cap−48.61%
GOSSGossamer Bio, Inc.$55.96MMicro cap+282.85%
RNTXRein Therapeutics Inc.$50.31MMicro cap−56.80%
520A.TJ-Pharma Co., Ltd.$49.31MMicro cap−41.86%
IMAImageneBio, Inc.$45.97MMicro cap−51.50%
NSRXNasus Pharma Ltd.$40.88MMicro cap−56.10%
GRCEGrace Therapeutics, Inc.$38.08MMicro cap−42.54%
SCYXSCYNEXIS, Inc.$37.91MMicro cap+405.98%
EDSAEdesa Biotech, Inc.$34.99MMicro cap−1.52%
NNVCNanoViricides, Inc.$34.73MMicro cap−15.53%
QNCXQuince Therapeutics Inc$32.27MMicro cap+84.80%
4884.TKringle Pharma, Inc.$30.61MMicro cap+36.08%
BRNSBarinthus Biotherapeutics PLC$30.23MMicro cap−41.73%
BOT.AXBotanix Pharmaceuticals Limited$25.20MMicro cap−90.71%
AARDAardvark Therapeutics, Inc.$23.64MMicro cap−90.76%
4591.TRibomic Inc.$23.33MMicro cap−29.03%
MCRBSeres Therapeutics, Inc.$19.89MMicro cap−88.47%
QNRXQuoin Pharmaceuticals, Ltd.$19.26MMicro cap−69.62%
VYNEVYNE Therapeutics Inc$19.07MMicro cap+7811.36%
COCPCocrystal Pharma, Inc.$18.72MMicro cap−20.98%
JSPRJasper Therapeutics, Inc.$16.82MMicro cap−78.31%
ATYRaTyr Pharma, Inc.$15.05MMicro cap−84.23%
4881.TFunPep Company Limited$13.83MMicro cap−56.57%
KTTAPasithea Therapeutics Corp.$13.36MMicro cap−43.52%
HINDVyome Holdings, Inc.$12.56MMicro cap−69.02%
TVRDTvardi Therapeutics, Inc.$11.23MMicro cap−82.71%
AZTRAzitra, Inc.$9.27MMicro cap+180.22%
IMC.AXImmuron Limited$9.06MMicro cap−56.52%
CALCCalciMedica, Inc.$8.88MMicro cap−57.10%
INMInMed Pharmaceuticals Inc.$8.74MMicro cap−22.06%
SNGXSoligenix, Inc.$7.94MMicro cap−77.56%
IMRNImmuron Limited$7.43MMicro cap−58.18%
CMMBChemomab Therapeutics Ltd.$7.33MMicro cap−67.21%
XCURExicure, Inc.$7.14MMicro cap−76.71%
PULMPulmatrix, Inc.$5.26MMicro cap−70.79%
GLMDGalmed Pharmaceuticals Ltd.$4.95MMicro cap+162.32%
JAGXJaguar Health, Inc.$3.97MMicro cap−96.70%
VBS.AXVectus Biosystems Limited$3.93MMicro cap−35.71%
BIT.AXBiotron Limited$3.91MMicro cap−33.33%
GRIGRI Bio, Inc.$3.28MMicro cap−97.35%
SXTP60 Degrees Pharmaceuticals, Inc.$3.05MMicro cap−85.34%
CVKDCadrenal Therapeutics, Inc.$2.82MMicro cap−93.05%
ANR.AXAnatara Lifesciences Ltd$2.00MMicro cap−35.71%
XRTXXORTX Therapeutics Inc.$1.93MMicro cap−68.02%
VBIOValion Bio, Inc.$1.76MMicro cap−70.00%
MTNBMatinas BioPharma Holdings, Inc.$1.63MMicro cap+8.36%
0R55.LBioSenic S.A.$26.40KMicro cap−20.00%
0A8U.LSynlogic, Inc.——−38.22%
0A9G.LMereo BioPharma Group plc——−86.42%
1AE.DEargenx SE——+0.19%
A1RG34.SAargenx SE—Mega cap−9.29%
A2RR34.SAArrowhead Pharmaceuticals, Inc.—Mid cap+36.34%
ABNX.PAABIONYX Pharma SA—Small cap−53.55%
ABVX.PAABIVAX Société Anonyme—Mid cap−1.08%
ALBPS.PABiophytis S.A.——−71.04%
ALDVI.PAAdvicenne S.A.——−61.72%
ALNEV.PANeovacs S.A.——−31.82%
ALTHX.PATHX Pharma Société Anonyme——+27.91%
ANNX.STAnnexin Pharmaceuticals AB (publ)—Small cap−68.45%
APLI.TOAppili Therapeutics Inc.——−66.67%
APTA.STAptahem AB (publ)——−79.45%
B1MR34.SABioMarin Pharmaceutical Inc.—Large cap−0.89%
BIOSGN.STBiosergen AB (publ)——−99.01%
BIOV.SWBioVersys AG——+2.90%
BPBS.PABIOPHYTIS BSA——0.00%
BSLN.SWBasilea Pharmaceutica AG——+39.09%
CAMX.STCamurus AB (publ)—Large cap−2.63%
CESSA.COCessatech A/S——−49.04%
CRDL.TOCardiol Therapeutics Inc.—Small cap−5.88%
CRNO-B.STCereno Scientific AB (publ)—Small cap−57.04%
CURN.SWCuratis Holding AG——+36.80%
DBV.PADBV Technologies S.A.—Small cap−41.82%
EPRX.TOEupraxia Pharmaceuticals Inc.—Small cap+26.16%
GNFT.PAGenfit S.A.—Small cap+128.93%
IMM.LImmuPharma plc——−65.96%
MDP.TOMedexus Pharmaceuticals Inc.—Small cap+68.51%
MSCL.TOSatellos Bioscience Inc.—Small cap+12.68%
PHGN.DEPharming Group N.V.——−31.40%
PHR.WAPharmena S.A.——−12.57%
REC.MIRecordati Industria Chimica e Farmaceutica S.p.A.—Large cap+5.26%
RVX.TOResverlogix Corp.——−20.00%
SANN.SWSanthera Pharmaceuticals Holding AG——+37.07%
STX.LShield Therapeutics plc—Small cap−30.07%
VRTX34.SAVertex Pharmaceuticals Incorporated—Mega cap−84.64%

Covers ~23,000 companies across the US, Europe and Asia-Pacific (ex mainland China, Hong Kong and India), refreshed nightly. Price and the 52-week distance are in the currency the stock trades in; only market values are converted.

We cover 227 companies grouped under the Rare disease theme. The median market value in the group is $340.09M. Among the 164 with a price from the latest session, the median move over the past trading day is +0.06%. 25% of the 214 with a 200-day average trade above it. Price change over the past year runs from −70.9% to +112.2% across the middle 80 percent of the group, with a median of −14.5%. Across the group, 1 company currently carries a tier A volume signal.

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